维吾尔医异常黑胆质证大鼠模型 z-bo 2020-12-26 314

　　Purpose: To evaluate and discuss the biological markers of a rat model of abnormal sava syndrome in Uyghur medicine by combining the observation of external characteristics and the study of urine metabolome.

　　Methods: Uyghur medical theory of abnormal savella was used to establish a rat animal model, and its various external indicators such as hair, tongue, sleep, feces, mood, weight growth rate, etc. were observed and scored, and the hydrogen nuclear magnetic resonance spectrum ( 1H-nuclear magnetic resonance, 1H-NMR) to detect and analyze its urine.

　　Results: Compared with the control group, the rats in the model group of abnormal sava biliary syndrome showed obvious changes in external characteristics, including dry and hard stools, decreased urine output and darkened color, dry fur, dark purple tongue coating with ecchymosis, weight growth rate Decrease, etc.; the content of 23 metabolites in urine metabolites is significantly reduced, including propionate, lactic acid, alanine, pyruvate, acetic acid, acetamide, glycoprotein, acetone, formin, sarcosine, ornithine. Glycine, creatine, creatinine, creatinine, β-galactose, urocanate, tyrosine, phenylalanine, hippuric acid, aminohippuric acid, formic acid, lysine, etc., and urea, citric acid ､The content of 4 metabolites including allantoin and α-ketoglutarate increased significantly.

　　Conclusion: During the occurrence and development of abnormal savella syndrome, rats in the model group not only changed their appearance, but also experienced obvious changes in various internal metabolic pathways. The obvious abnormality of urine metabolites may be related to abnormal savella syndrome. Related to the biological mechanism.