慢性输卵管炎性不孕症大鼠模型 z-bo 2020-12-28 386

　　Objective: To establish a rat model of acute and chronic tubal inflammatory infertility using Staphylococcus aureus. Method: Prepare 4×109/mL Staphylococcus aureus suspension. 108 rats were randomly divided into normal group, model group, sham operation group, 36 rats in each group. Model group was injected with S. aureus suspension through fallopian tube, sham In the operation group, normal saline was injected through the fallopian tube; on the 7th, 14th, 21st, and 28th day after the operation, the morphological changes of the fallopian tube were visually observed, and Staphylococcus aureus culture and pathological examination were performed.

　　Result: Injecting Staphylococcus aureus through the fallopian tube can form an acute tubal inflammatory model on the 7th day after surgery, a chronic tubal inflammatory model on the 21st day, and a tubal inflammatory infertility model on the 28th day.

　　 Conclusion: Using Staphylococcus aureus at a concentration of 4×109/mL and injected into the fallopian tube of rats can successfully establish rat models of acute salpingitis and chronic tubal inflammatory infertility.