小鼠痔疮模型 z-bo 2020-12-30 321

　　Objective: To study the protective effect of hemorrhoids magnetic ointment on mice with hemorrhoids induced by acetic acid.

　　Methods: Forty SPF ICR mice were divided into normal group (10) and model group (30). The model group was built with 20% acetic acid to establish a hemorrhoid model, and the model group was divided into model group 24 hours after the model was successfully modeled. , Hemorrhoids magnetic ointment group and Mayinglong Musk hemorrhoids ointment group, and corresponding treatment. Perianal score was performed 11 days after treatment, CBA kit was used to detect peripheral blood IL-6, IL-1β and TNF-α levels, Griess kit was used to detect peripheral blood nitric oxide (NO) content, and hematoxylin-eosin (HE) staining evaluation Pathological changes of rectal tissue. Results: Compared with the normal group, the perianal score of the model group was significantly increased, the rectal tissue was severely injured, and the levels of IL-6, IL-1β, TNF-α, and NO in the peripheral blood increased significantly; compared with the model group, each treatment The perianal score of the drug group was significantly reduced, the pathological damage of rectal tissue was significantly improved, and the levels of peripheral blood L-6, IL-1β, TNF-α and NO were significantly suppressed.

　　Conclusion: Hemorrhoids Magnetizing Ointment has a good therapeutic effect on mice hemorrhoids model, and this therapeutic effect is closely related to the regulation of the level of inflammation in the body.