大鼠局灶性脑缺血模型,动物造模 z-bo 2021-10-28 425

　　Objective: To analyze and evaluate the correlation between the three suture methods for successfully preparing a rat focal cerebral ischemia model, and to provide new methods and standards for evaluating the model.

　　 Method: A total of (30) male SD rats were randomly divided into a sham operation group (n = 15) and a model group (n = 15). To slightly improve preparation for focal cerebral ischemia, see Zea-Longa suture. The cerebral blood flow changes of each group of models and rats were detected before and after the operation. Taking rat cerebral infarction area as the gold standard, we will analyze the correlation between this standard and changes in cerebral blood flow.

　　Result: The proportion of cerebral infarction area in model rats is positively correlated with changes in cerebral blood flow, and has nothing to do with behavioral scores.

　　 Conclusion: The change of cerebral blood flow in rats can be used as a criterion for evaluating the success of a model of focal cerebral ischemia.