动物造模,腰椎板开窗术后微小骨粒回植模型 z-bo 2021-01-07 364

　　Objective: To establish a model of microbone granule replantation after lumbar lamina fenestration, and to provide clinical experimental evidence.

　　Method: Divide 18 New Zealand male rabbits into two groups. In the control group, after general anesthesia, with the L5 spinous process as the center, the left L5 vertebral plate was completely exposed, and the vertebral plate and f flesh were slowly bitten with a microgun. The window rate was about 0.8x0. A 3 cm bone window is exposed. Then sew immediately. After opening the window on the left side of L5, the experimental group cut off the bone fragments bitten by the window, put the bone fragments into a medical collagen sponge to form a bow-shaped bridge, placed it on the epidural window, and sutured the incision. done. After the operation, observe the CT and histological changes of the lamina opening.

　　Result: The result of CT examination was that the small bone particles of the experimental group formed a thin bone plate at the opening of the window 8 weeks after the operation, and the bone plate formed after 12 weeks was thick and the small bones were continuous. , There is no significant change in the shape or volume of the spinal canal. The spinal cord is squeezed. The control group had a small amount of bone hyperplasia at 8 weeks and 12 weeks after the window was opened, the surrounding adhesion tissue invaded the spinal canal, and the spinal canal was not reconstructed.

　　 Conclusion: By re-implanting your own small bone particles in the opening of the rabbit lamina to rebuild the bone, you can prevent the scar from invading the spinal canal and reduce the adhesion of the spinal canal.