动物造模,生长激素缺乏动物模型 z-bo 2022-01-27 548

　　Objective: To explore several methods for establishing adult growth hormone deficiency animal models, and provide a good model for experimental research and treatment of abnormal bone metabolism caused by growth hormone deficiency.

　　Method: Reference literature to identify and evaluate how to establish an animal model of adult growth hormone deficiency.

　　Result: Adult growth hormone deficiency animal models can be divided into three types: spontaneous growth hormone deficiency animal models, pituitary resection animal models and gene knockout models.

　　Conclusion: The animal models of hypophysectomy are cheap and easy to operate, but there are many factors that affect them. Not suitable for studying the relationship between growth hormone and bone metabolism. Spontaneous growth hormone deficiency animal models and gene knockout animal models are expensive, but the specific growth hormone deficiency is suitable for studying the effect of growth hormone deficiency on bone metabolism.