动物造模,阿尔茨海默病树鼩模型 z-bo 2021-11-17 313

　　Objective: To analyze the brain imaging characteristics of Schrew, a model tree of Alzheimer's disease (AD).

　　Method: Aβ1-40 was injected into the upper ventricle of the stereotaxic device to establish an AD animal model. After confirming the success of the model through visuospatial behavior testing, MRI was used for coronary artery T2 enhanced imaging (T2WI) and diffusion tensor imaging (DTI) analysis.

　　 Results: The reference memory errors (3 weeks, 4 weeks) and working memory errors (2 weeks, 3 weeks, 4 weeks) of the model group were significantly higher than those of the control group (P\u003c0.05). ). The time it took for the model group to complete the task (2 weeks, 3 weeks) was significantly longer than that of the control group (P\u003c0.05). Starting from 3 weeks, the number of trees in the model group decreased in unilateral or bilateral hippocampus, and the corresponding lateral or bilateral ventricles increased. After 12 weeks, the width of the bilateral temporal horns of the branches of the model group was significantly larger than that of the control and treatment groups (P\u003c0.01). The diffusion tensor imaging scan showed that the apparent diffusion coefficient (ACD) on both sides of the tree-shaped Schrew Kaiba of the model group was higher than that of the control group (P\u003c0.01). The model group Corpus Calsom fiber bundle was obviously missing.

　　 Conclusion: When Aβ1-40 is injected into the lateral ventricle, the tree breaks can cause learning and memory problems. MRI can show the characteristic changes in AD Tree Schlubrain. The width of the temporal horn, the ADC value of the hippocampus and the damage to the cal body fibers are the criteria for diagnosing dementia.