动物造模,大脑中动脉栓塞模型 z-bo 2021-01-08 357

　　OBJECTIVE: To compare the timeliness, success rate and mortality of the rat middle cerebral artery embolization model established by conventional carotid artery puncture and conventional suture.

　　 Method: 32 male rats were randomly divided into common carotid artery puncture group and conventional suture group, and suture was inserted from common carotid artery to embolize the middle cerebral artery. Using the Bedson neurological function scoring standard, we scored the neurological function 24 hours after the operation, and calculated the 24-hour success rate and mortality rate.

　　Result: The time, success rate and mortality rate of the MCAO model established by ordinary carotid artery puncture and conventional surgical methods were (82.3±17.4) seconds and (164.6±22.0) seconds, respectively. big difference. P0.05); 6.25% and 18.75%, no significant difference (P\→0.05).

　　 Conclusion: It is easy to prepare a rat middle cerebral artery embolization model by common carotid artery puncture, saving time, less trauma and easy to operate.