动物造模,功能性消化不良脾虚证大鼠模型 z-bo 2022-01-13 402

　　Objective: To explore the establishment and comparison of animal models of functional dyspepsia with spleen deficiency syndrome.

　　 Method: use iodoacetyl group and joint small platform standing method or joint swimming method to establish functional dyspepsia and spleen deficiency rat models. The general condition of the animal, changes in body weight and food intake, the contents of serum motilin, cholecystokinin, lactic acid and gastrin, and the excretion rate of D-xylose in urine were used to evaluate the shaping effect.

　　Result: Rats in the iodoacetamide single factor group have slower body weight and reduced food intake. Rats in the complex factor group showed symptoms of spleen deficiency, such as weight loss, curly hair, diarrhea, urinary D-xylose excretion and serum gastric motility. The content of gastrin and gastrin decreased significantly, but the content of serum cholecystokinin and lactic acid increased significantly.

　　 Conclusion: The three modeling methods will all cause the symptoms of functional dyspepsia, but the symptoms of spleen deficiency are more obvious in the complex factor treatment group, and the iodoacetamide complex small platform standing method is the best choice.