动物造模,大鼠蛛网膜下腔出血模型 z-bo 2021-01-11 996

　　Objective: To introduce in detail how to create a rat submucosal hemorrhage model by combining graphics and text, and to improve and innovate the model to better simulate submucosal hemorrhage caused by clinical aneurysm rupture. 

　　Method: Select SD male rats, and use the method of penetrating the inner and extracranial parts of the neck into the neck to establish a submucosal hemorrhage model of the SD male rat, breathing, pupils, urine, excrement and anatomical size with the indwelling fiber core mouse. Validate the model with head and neck methods. Through observing mortality and clinical symptoms, the controllability and repeatability of the model were discussed.

　　Result: Blood vessel puncture will cause submucosal bleeding, and the position of the fiber core can accurately puncture the required blood vessel.

　　Conclusion: The method is stable, easy to understand, well-designed, flexible and repeatable. After understanding, the model can be successfully modeled in a short time, and the submucosal hemorrhage caused by the successful model can be improved. It simulates the sudden rupture and bleeding of a clinical aneurysm. This is very suitable for studying early brain damage and vasospasm of submucosal hemorrhage.