动物造模,食蟹猴急性心肌梗死模型 z-bio 2021-01-14 375

　　Purpose: Do you want to use ECG to observe the changes in left ventricular function of cynomolgus monkeys with electrocardiogram infarction (AMI), and to provide reference for the AMI model of cynomolgus monkeys?

　　Method: Create each crab-eating monkey. In front of the model? Three days after modeling and one month after modeling, an echocardiogram was performed to observe changes in left ventricular morphology, hemodynamics, blood flow velocity of mitral valve opening, and annulus tissue migration rate. Results Compared with the pre-modeling, the thickness of the left ventricular posterior wall (LVposteriorthicknessatend-diastole, LVPWd) of the cynomolgus monkey was significantly increased at 3 days (P\u003c0.05) and the left ventricular systole (LVID) after modeling. After 1 month, the elasticity increased significantly (P\u003c0.05). At the same time, the left ventricular drainage rate (LV drainage rate, LVEF), stroke volume (SV), left ventricle, short axis shortening rate of cynomolgus monkeys (LV score shortened, LVFS) were significantly reduced on day 3 and 1 month later (LV score) Shortened, LVFS) (P\u003c0.05, P\u003c0.01), cardiac output (CO) decreased significantly one month after modeling (P\u003c0.05). Does the hourly heart rate (HR) increase significantly (P\u003c0.05)? Conclusion: Echocardiography technology can be used to evaluate the left ventricular function of the candy monkey AMI model. Especially LVEF? SV? LVFS index can reflect AMI. Degree; Are the echocardiographic evaluation results of the cynomolgus monkey AMI model similar to those of human AMI disease?