动物造模,高尿酸血症及并其发症大鼠模型 z-bio 2021-12-01 374

　　Objective: To establish a stable and efficient model of liver and kidney damage, severe arthritis and other complications in hyperuricemia rats.

　　Methods: 48 male Sprague-Dawley rats (hereinafter referred to as SD rats) were randomly divided into 6 groups (8 rats in each group), namely, the blank control group (control group) and the oxazine potassium group (OA group) . ). , Potassium oxalate + hypoxanthine group (OA + H group), potassium oxalate + yeast extract group (OA + YE group), 10% fructose + 0.2% etabaol group (10% Fru + 0.2% EMB group) , 2 After 5 weeks of experiment with 5 different drugs, different concentrations of% potassium oxalate and 12% yeast special diet group (OAPO group), the rats' serum uric acid, creatinine, urea and other biochemical indicators were measured and measured Now, the pathological section observation of joint synovial muscle.

　　Result: Compared with the blank control group, the serum uric acid level of the OAPO group was increased, severe liver and kidney damage and joint inflammation. The OA, OA + H, OA + YE, 10% Fru + 0.2% EMB group did not reach high uric acid levels, but some liver and kidney damage and joint inflammation did occur.

　　Conclusion: The mixed diet of 2% potassium oxalate and 12% yeast extract is the most effective way to establish a model of hyperuricemia and complications. This model is also suitable for studying kidney damage and joint inflammation caused by hyperuricemia.