动物造模,黄褐斑动物模型 z-bio 2021-12-02 616

　　Objective: To analyze the application of croazuma animal models through animal experiments, explore the theoretical knowledge of croazuma, explore new therapies, develop new drugs, and improve the scientific, strict and safe treatment level of croazuma. 

　　 Method: Search croazuma's experimental research literature in CNKI, Wanfan database and weapon database based on "Cruzuma". The time ranges are "1960-2019, 1990-2019, 1979-2019". .. Summarize and analyze indicator tests related to the application of animal models in the literature.

　　 Using female KM mice to replicate Croazuma animal models is the most common method, and the modeling method is most commonly used for UV light. The most common modeling time is 30 days, with a minimum of 7 days or more. The administration time is mainly distributed between 28 to 31 days. The measurement of indicators is divided into apparent indicators, biochemical indicators and pathological indicators. The main focus is on the detection of biochemical indicators. The focus of these biochemical indicators is the changes in skin and serum related to oxidation factors.

　　 Conclusion: The current experimental research and theoretical discussion on croazuma and the status quo of croazuma have not been seriously balanced. Animal experimental research should be increased. The establishment of complex animal models and animal models with the characteristics of TCM disease is an important development direction in the future. In addition, the research on the mechanism of drug action is limited to the imbalance between the surface of the body and the oxidation and antioxidants in the body, while ignoring related factors such as endocrine disorders. Proposals and detailed studies on the "Neuroendocrine and Immunity" (NEI) network on the surface of the human body. In Crozuma treatment, whether the NEI network on the human body and the surface of the body can be adjusted to exert overall and local therapeutic effects.