动物造模,小型猪肥胖模型 z-bio 2021-11-16 311

　　Objective: To explore the effect of high-fat and high-sugar diet on fat distribution and blood biochemical indexes of Parmani pigs.

　　 Method: 14 Bama miniature pigs, 8 experimental groups, type 2 diabetes susceptible pigs raised in our laboratory, high-fat and high-sugar diet for 30 weeks, and the control group 6 fed a normal diet. After 30 weeks, measure the body shape coefficient, CT scan fat content and biochemical index blood samples to compare the differences between the experimental group and the control group.

　　Result: After 30 weeks of high-fat and high-sugar diet, there were significant differences in body weight, body mass index (BMI) and total fat content between the experimental group and the control group (P\u003c0.05). , The visceral fat content is very significant (P\u003c 0.01); the blood biochemical indicators of insulin, total cholesterol, high-density lipoprotein cholesterol and triglycerides are very different from the control group (P\u003c 0.01). u003c0.01), the low-density lipoprotein cholesterol is significantly different from the control group (P\u003c 0.05). In addition, the serum protein and creatinine of the experimental group of Bamamin pigs were significantly different from the control group (P\u003c0.05), and uric acid and urea were significantly different from the control group (P\u003c0.01). The minipigs in the experimental group had kidney damage. It shows that it shows.

　　 Conclusion: High-fat and high-sugar diet can cause fat accumulation in Parmani pigs, especially visceral fat accumulation. Blood biochemical indicators indicate hyperlipidemia and renal insufficiency.