动物实验 z-bio 2021-01-20 298

　　Artificial memory can be produced during sleep, which is the conclusion of a research report published online in "Nature-Neuroscience". The study pointed out that when mice sleep, their brains can associate a certain reward with a specific location, and this association can drive the mice to produce corresponding behaviors after they wake up.

　　 Location cells are a type of cells that exist in the hippocampus of the brain. When an animal is in a certain position in the environment, the location cells are activated. The active patterns generated in these cells when the animal walks will be "played" again when the animal sleeps. This behavior is thought to help consolidate and strengthen the animal's cognitive map of the environment.

　　 Karim Benchenane et al. stimulated the reward pathway of the brain in 5 mice in sleep, where cells in the brain are encoding specific environmental locations. Another 2 mice received non-reward stimulation. When they wake up, only those mice that have received a reward stimulus related to cell activation in a specific location will spend more time in the cell-encoded location, which indicates that artificial memory has been formed when the mouse brain is at rest .

　　 Previous studies have shown that the memory of mice can be manipulated. And this study is the first to show that the memory of sleeping animals is manipulated by humans. However, whether this memory manipulation can be realized in humans is still unknown.