哺乳动物 z-bio 2021-11-06 311

　　The development of the mammalian brain is a complex and orderly process that is highly precisely regulated. After a long period of exploration and research, scientists have gained a certain understanding of brain development and established some basic rules.

　　 Neuron migration is an indispensable and important link in brain development. Immature neurons follow a certain migration pattern to reach the correct location, and finally form a highly complex neural circuit. Classical theories in the past believed that excitatory main neurons migrate radially along radial glial cells, while inhibitory interneurons mainly migrate tangentially. These migration patterns are of great significance to brain function and are the basis for the formation of complex neural networks.

　　 Hongjun Song and Guo-Li Ming of Johns Hopkins University recently challenged the above-mentioned basic rules. Their research showed that excitatory neuron precursors exhibit tangential migration in the brains of adult mammals. This surprising discovery was published in PNAS, the Proceedings of the National Academy of Sciences on July 13. Song Hongjun and Ming Guoli are a couple of immortals. They have been in love since they were studying at Peking University. Now they are complementary in their careers and have achieved one after another in the field of neuroscience. More than 60 research papers have been signed and published in international authoritative academic journals such as Cell, PNAS, and Nat Neurosci.

　　 Researchers at Johns Hopkins University conducted an in-depth analysis of excitatory neuron precursors in the dentate gyrus of the mouse brain and found significant tangential migration behavior. Further research shows that this tangential migration mainly occurs in the neuroblast stage.

　　 This research has further enriched people's understanding of mammalian neurodevelopment and laid an important conceptual foundation for studying brain plasticity, brain diseases, and brain repair.