动物造模,大鼠颅骨缺损后软组织再生 z-bio 2021-01-27 305

　　Objective: To evaluate the ability of two new types of citric acid-degrading biomaterials to induce soft tissue regeneration after skull defects in rats.

　　Methods: 46 male Sprague Dawley rats and 6 SD rats were randomly selected and transplanted to the femoral muscle. Two weeks later, materials were collected. The remaining 40 skull defects were randomly divided into 4 groups, divided into control group, 3 after autologous treatment The bone transplantation group and two new citrate material transplantation groups (each group includes 10 animals) were performed histological staining and morphological analysis, and samples were taken. Results: 1.2 Two new citric acid biomaterials can induce muscle and soft tissue regeneration; 2. Two new citric acid biomaterials are blood vessels and fibrous tissues of rats with skull defects, which can induce regeneration; 3.2 Two new biomaterials It accelerates the formation of intramembranous bone after skull defect by inducing soft tissue regeneration.

　　Conclusion: Both biomaterials have excellent soft tissue regeneration inducing ability, which can effectively stimulate the regeneration of soft tissue during skull defect, accelerate the development of intracranial ossification, and ultimately heal the skull.