动物造模,大鼠胫骨骨缺损修复 z-bio 2021-10-22 303

　　Objective: To observe the effect of calcium phosphate cement (CPC) and lithium chloride composite calcium phosphate cement (Li/CPC) on fracture healing in SD rats. Method: Collect 20 6-month-old female SD rats, set up Li/CPC experimental group (n = 10) and CPC control group (n = 10), and perform bilateral tibial defect filling surgery for 1 day. done. In February, 5 rats in each group were sacrificed, tibia specimens were taken for Micro-CT (Micro-CT) detection, and HE staining of tissue sections was compared and analyzed.

　　 Results: Micro CT scan showed that the Li/CPC group repaired bone defects more effectively than the CPC group. The volume of new bone (BV/TV) around the Li/CPC material is higher than that of the CPC group, and the trabecular spacing (Tb).Sp) is smaller. The difference is statistically significant (P\u003c0.05). Histological HE staining shows Fibrous and bony curls appear early. In the Li/CPC group, the number of CPC groups was higher, and the quality of bone healing was significantly higher.

　　 Conclusion: Li/CPC has excellent bone conduction properties, which can significantly accelerate the repair of bone defects.