动物造模,紫外线损伤小鼠 z-bio 2021-11-17 309

　　Objective: To study the protective effect of ginseng coenzyme Q10 sunscreen on mice damaged by ultraviolet rays.

　　Method: 36 mice were randomly divided into groups. After the skin was depilated, the corresponding cream was applied respectively. The normal control group did not do any treatment, and the other groups were irradiated with ultraviolet rays. After 8 consecutive weeks, the mice were blooded and sacrificed for index detection.

　　Results: Compared with the normal group of mice, the model group had rough skin with wrinkles and stratum corneum, the activities of T-SOD and GSH-Px were significantly decreased, and the number of white blood cells and MDA content were significantly increased (P<0.05); Compared with the groups, the skin of mice in the ginseng coenzyme Q10 sunscreen group was smooth, the stratum corneum did not fall off, T-SOD activity, red blood cell and hemoglobin content increased, and the number of white blood cells and MDA content decreased significantly (P<0.05). The skin of the positive control group mice The stratum corneum was smooth, the stratum corneum was not shedding, the activity of GSH-Px increased, and the number of white blood cells and MDA content decreased (P<0.05).

　　Conclusion: Ginseng coenzyme Q10 sunscreen has the effect of anti-ultraviolet rays, and its preventive effect is equivalent to that of methoxycinnamate coenzyme Q10 cream.