动物造模 z-bio 2021-02-01 301

　　Objective: To evaluate the effects of continuous high frequency sine wave and square wave stroboscopic on emmetropia and eye development in guinea pigs.

　　Method: 30 2-week-old guinea pigs were divided into 3 groups (n = 10): 20 Hz square wave, 20 Hz sine wave stroboscopic observation group, non-flicker control group (n = 10), uniform light intensity 500 lx, each The refractive power of the guinea pigs was measured for two weeks, and the length and radius of curvature of the axis were measured. At the 8th week, three groups of guinea pigs were subjected to electrophysiological flash electroretinogram (F-ERG). Check and perform histopathological evaluation after eyeball removal.

　　Results: The eye refractive power of the guinea pig group 3 was positively correlated with the axial length. At 8 weeks (-0.75), compared with the control group, there were 20Hz sine strobe group and 20Hz square wave refractive power. 0.79) D and (-1.50±0.91) D myopia changes (P0.05), the F-ERG latency of the 20Hz sine wave and 20Hz square wave stroboscope group is a wave lengthened by 3.8 seconds and 7.9 seconds, respectively, no significant Significant difference. Histology between the three pathology groups.

　　Conclusion: Continuous exposure to high-frequency square waves and sinusoidal stroboscope flash will affect the face up to a certain extent.