动物造模,2型糖尿病肾病大鼠模型 z-bio 2021-02-02 303

　　Objective: How to investigate the effect of feeding time on the blood glucose, insulin resistance index (HOMA-IR) and urinary albumin excretion rate (UAER) of a rat model of type 2 diabetic nephropathy by a variety of high-fat diets?

　　 Method: Use unilateral renal artery ligation + high-fat diet feeding + low-dose streptozotocin (STZ) intraperitoneal injection to establish a model. After ligating the unilateral renal artery, the DN1 and DN2 groups were given a high-fat diet four times. A few weeks or eight weeks. After 4 weeks, STZ 30 mg/kg was injected intraperitoneally, and the UAER of the two groups of rats were compared 4 weeks after STZ injection and at the end of the experiment. Observe blood sugar, body weight and HOMA-. IR, renal index and kidney pathology of the two groups of rats.

　　Result: 4 weeks after STZ injection, the UAER of both groups of rats may increase, and the UAER of the DN2 group was significantly higher than that of the DN1 group. Group (P0.05)?

　　 Conclusion: Increasing the feeding time of a high-fat diet may increase DN renal damage, but should this study consider options because this may delay the intervention time?