动物造模 z-bio 2021-02-03 406

　　Objective: How to study the influence of inflammatory factors, lipid metabolism and glucose metabolism on body weight in the acute phase of AIDS? Methods: Acute inflammatory factors (TNF-α? IL-6) and lipid metabolism (cholesterol? triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol) and glucose metabolism parameters (insulin-insulin resistance index)), To compare the differences between the weight gain and weight loss groups of SIV-infected Beiping monkeys, did we check the Pearson correlation analysis of the relationship between insulin resistance and plasma viral load?

　　 Results: In the acute phase of SIVmac239 infection in Beiping-top monkeys, the weight gain group and the weight loss group; in the weight gain group, there was no significant difference between the four items of inflammatory factors and plasma lipids. Insulin levels decreased, insulin levels increased significantly in the weight loss group, and insulin resistance appeared; Pearson analysis showed that the 5th and 11th insulin resistance index plasma viruses changed in 1 week after infection. Is there a positive correlation with load?

　　 Conclusion: SIVmac239 infection is acute. During this period, could abnormal glucose metabolism be the main reason for the weight change of Beiping monkeys?