动物造模 z-bio 2021-02-03 340

　　Objective: To investigate the effect of different doses of perfluorooctane sulfonic acid (PFOS) on the development of placental embryos and the expression of insulin-like growth factor IGF-1 (insulin-like growth factor IGF-1)?

　　Method: 48 SD female rats with 12 days of gestation were randomly divided into 4 groups and were given different doses of PFOS (0, 5, 10, 20 mg/kg) and gavage for 7 days. On the 19th day of pregnancy. quality? Fetal rat liver coefficient? What are the serum PFOS and glucocorticoid (GC) levels in pregnant mice? Placental IGF-1 expression?

　　Results: With the increase of the dose of PFOS, compared with the control group, the exposure group became significantly accumulating PFOS, the weight of the pregnant rats, the weight and length of the fetus, and the weight of the placenta. Decrease gradually, the difference of PFOS was significant in the 20 mg/kg group (P\u003c0.001), the liver index of fetal rats showed the same trend, and the doses of the low, medium and high addiction groups were higher than The control group was also significantly lower than the control group (P \u003c0.05). (U003c0.05), and blood biochemical alanine aminotransferase (ALT) and aspartate aminotransferase (AST) also increased with the increase of PFOS dose. Increase (P\u003c0.05); The serum GC level of pregnant mice in the PFOS 10 mg/kg group increased (P\u003c0.05); As the dose of PFOS increases, the expression level of placental IGF-1 decreases?

　　Conclusion: Long-term exposure to PFOS during pregnancy can lead to the accumulation of serum PFOS in pregnant mice, which in turn causes liver toxicity, increased GC content and decreased IGF-1 expression in the placenta of fetal mice, and ultimately affects it Grow. And the development of fetal mice?