动物造模 z-bio 2021-11-06 393

　　Objective: How to study the effect of Maiqi Jiangtang Pills on the blood glucose level of ob/ob mice? Methods: Eight-week-old male ob/ob mice were randomly divided into model groups, and they were given high, medium and low doses (8 g/kg? 4 g/kg? 2 g/kg) to take Maiqi Jiangtang pills and metformin (250 mg) group. Corresponding to / kg) group and the drug dose of each administration group once a day for 10 consecutive weeks, and the same amount of solvent was applied to 6J mice of the same age as the normal control group C57BL and model control group ob/ob mice, Did you give it? Is it possible to detect the average daily food intake and body weight of each group of mice? Fasting blood sugar? Serum insulin levels and pathological changes of the pancreas?

　　Result: The 2 weeks, 6 weeks, 8 weeks and 10 weeks administration of Maiqi Jiangtang pills can significantly reduce the fasting blood glucose of ob/ob mice (P\u003c0.05, P\u003c0.01). Within 10 weeks, there was no significant effect on the average daily food intake and body weight of the mice. Can it reduce the pathological changes of pancreatic islet cells in ob/ob mice and increase the fasting serum insulin levels in ob/ob mice (P\u003c0.05)?

　　 Conclusion: Maiqi Jiangtang pills can reduce blood sugar levels in ob/ob mice, but are they related to reducing the pathological damage of the pancreas and promoting insulin secretion?