MAIT细胞 z-bio 2021-02-16 349

　　Mucosal-associated invariant T cell (MAIT) is a subgroup of T cells that is important for mucosal homeostasis. These cells can recognize the vitamin B2 precursor derived from the microbiota, but can also be activated by certain cytokines in the case of viral infection. Provine et al. reported that ChAdOx1, a leading adenovirus vector vaccine, activated MAIT cells in immunized mice. This activation requires interferon-α produced by plasmacytoid dendritic cells and monocyte-derived interleukin-18 (IL-18) and tumor necrosis factor. MAIT cell activation is positively correlated with vaccine-mediated T cell responses in human subjects. Mice lacking MAIT cells have impaired immunity to CD8+ T cells of the target antigen after vaccination. This research suggests an additional way to improve the efficacy of vaccines.