造血干细胞 z-bio 2021-02-17 323

　　Hematopoietic stem cells (HSCs) located in the bone marrow can produce all the blood cells of the body, including key immune cells that can protect the body against bacterial and viral infections. As the body ages, HSCs will become no longer effective and will not produce Healthy new blood cells. In a research report published in the international journal Nature a few days ago, scientists from Albert Einstein College of Medicine and other institutions found through research that the reduction in the efficiency of HSCs may be partly due to the autophagy process mediated by molecular chaperones ( CMA (chaperone-mediated autophagy) is caused by degradation, which is a "housekeeping process" that can help remove damaged proteins and other waste products that interfere with cell functions.

　　Ana Maria Cuervo, MD, said that the aging of HSCs in the body’s bone marrow is inevitable, but the good news is that the process may be reversible; in this study, we studied mice and found that we developed a special drug Or it can activate the CMA process and potentially restore the vitality of HSCs in the elderly. In previous studies, researchers found that the decline of CMA function may help waste products accumulate in cells, thereby promoting the general population to suffer from Parkinson’s disease, Alzheimer’s disease and aging, and accelerating the CMA process will help effectively prevent the above The course of the disease; in this study, the researchers investigated whether the age-related decline of CMA plays a key role in the decline of HSC activity. The researchers said that the CMA process in mouse HSCs does indeed occur as the body ages. With decreased function, HSCs rely on the CMA process to protect their activity, while maintaining a healthy balance of proteins in cells, and can switch from a normal dormant state to an active blood cell formation stage.