自发白血病,动物模型 z-bo 2020-08-03 734

　　AKR spontaneous leukemia mice are born with carcinogenic RNA viruses, and their response to drug treatment is similar to childhood acute lymphoblastic leukemia (ALL).

　　[Characteristics of the model] AKR mice are a strain prone to leukemia. The incidence of lymphocytic leukemia is 76% to 90% in males and 68% to 90% in females. 6-12 months old AKR mice have enlarged spleen and lymph nodes and abnormal blood picture. Leukemia has a different course in each mouse, and on the second day after the leukemia is confirmed by a blood test, pairing and grouping can be started, and drug administration can be studied and the results can be observed. The observed indicators include peripheral blood images, white blood cell count, lymph node and spleen size, and animal survival rate. The effective survival period of patients was longer than that of the control group, and the effects of drugs in inducing and maintaining remission were evaluated based on hematology.

　　[Model Evaluation and Application] Spontaneous tumors in AKR mouse leukemia models are usually more similar than human tumors, rather than tumors induced by experimental methods, and the results of animal experiments are pushed to humans. The conditions are relatively natural. Through careful observation and statistical analysis, undiscovered environmental or other carcinogens can be found. We can focus on the role of genetic factors in tumorigenesis. The cause of spontaneous tumors in animals usually depends on the genetic characteristics of animals, which is far from the genetic characteristics of humans. The tumor growth rate of various animals is very different, and it is difficult to obtain a large number of tumor-bearing animals that grow uniformly within a certain period of time, resulting in defects such as long observation time and high experimental cost. Therefore, animal models of spontaneous tumors are rarely widely used in conventional anti-tumor drug screening.