动物实验 z-bio 2021-11-01 434

　　Zebrafish are popular in aquariums around the world and are native to South Asia. However, at the Cincinnati Children's Institute, the freshwater mutants here play an important role in scientific discoveries.

　　The iconic stripes are eye-catching, but this is the transparency of zebrafish embryo tissue. For researchers like Oriana Zinani, a fifth-year student in molecular development biology at the University of Cincinnati School of Medicine, this is crucial. The zebrafish spine pattern has a striped appearance and is controlled by segmented genes like a clock.

　　Zinani is Ertu, associate professor of pediatrics at UC and Cincinnati Children's Hospital Medical Center? I am a member of the team of scientists in the laboratory of Dr. rul M. Zbudak. The team is studying the genetic mutations that cause congenital scoliosis. This mutation is a congenital defect characterized by the inability to separate the vertebrae from the chaotic ribs. Zebrafish eggs are fertilized and developed outside the mother's body, making it easy for researchers to visualize in high-resolution images. Zebrafish and humans share 70% of the same genes.

　　You can see exactly what is happening in zebrafish and gain insight into the development of human embryos. My research raises a question: "How can zebrafish embryos ensure precise development in different environments, taking into account temperature fluctuations and exposure to different oxygenation levels?". We realized that embryos need to establish a mechanism to eliminate noise. "