动物造模,大鼠颅骨缺损动物模型 z-bio 2022-01-22 374

　　Objective: To explore an ideal method to establish a rat skull defect model and to improve the success rate of animal models of bone defect.

　　Method: Select 40 adult male SD rats and randomly divide them into control group and experimental group. The control group used the conventional skull defect model surgery procedure, using only a hollow ring drill perpendicular to the surface of the skull to complete the hole. -The thickness skull defect experimental group adopted an improved surgical method, using hollow drills and solid drills to guide the force of the drill at each stage of the skull drilling process. Compare the surgical operation time of the two models and whether there are complications such as periosteum, dura mater, brain tissue damage and hemorrhage during the operation, and the situation of the alumina bioceramic material implanted in the two models within 8 weeks. Compare loosening and osseointegration and the success rate of establishing models between the two groups.

　　Results: Compared with the control group, the surgical excavation time of the experimental group was significantly shortened (P\u003c0.01), and intraoperative complications such as periosteum, dura mater, brain tissue damage and bleeding were significantly reduced (P\u003c0) .01) . After the operation, the alumina bioceramic material did not shift or loosen (P\u003c005), the material was well integrated with the skull, and the modeling success rate was significantly improved (P\u003c0.). 05).

　　Conclusion: An improved method for constructing a rat skull defect model has the advantages of short surgical drilling time, fewer complications, can significantly improve the success rate of the model, and can be formed in vivo. It can effectively evaluate the bone of the rat skull defect model. Repair performance.