动物造模,关节炎小鼠模型 z-bio 2022-01-06 661

　　Objective: To establish and analyze the arthritis model of Staphylococcus aureus conditioned infection, and provide an animal model for studying the mechanism of arthritis and drug development.

　　Method: first treat mice with cyclophosphamide immunosuppression, and then inoculate the tail vein with Staphylococcus aureus, and model by observing joint appearance characteristics, arthritis index analysis and pathological observation score.

　　Result: From the first day of vaccination, the joints of the mice were slightly swollen, and the joint tissue damage went from a small amount of synovial hyperplasia and irregular placement to thickening of the synovial membrane, expansion and infiltration into the joint cavity. Pathological changes such as infiltration.

　　Conclusion: The successful establishment of a SA model of conditional infection can simulate the clinical symptoms and course of human arthritis in a relatively short time, and reflect the etiology of human arthritis from the aspects of infection and immune mechanisms.