动物造模,裸鼠人来源性子宫腺肌病 z-bio 2021-11-06 447

　　Objective: Through a variety of modeling techniques, select ideal modeling techniques and study the treatment plan related to the cause of adenomyosis, and establish an ideal animal model to establish a nude mouse model of human adenomyosis.

　　Method: 80 female nude mice were randomly divided into abdominal transplantation group, subcutaneous transplantation group, intraperitoneal injection group and subcutaneous injection group, 20 in each group. Each model group uses different modeling methods to build human models of nude mouse adenomyosis. The volume and tissue morphology of the graft were observed 4 weeks after operation.

　　Results: The modelling success rate of the abdominal implant group was 95%, the modelling success rate of the subcutaneous implant group was 45%, and the modelling success rate of intraperitoneal and subcutaneous injection was 0%.

　　Conclusion: The nude mouse model of adenomyosis established by peritoneal transplantation is an ideal human-derived adenomyosis animal model, with a high modeling rate and good stability.