动物造模,消化不良脾虚证大鼠模型 z-bio 2021-02-25 448

　　Objective: To explore the establishment and comparison of animal models of functional dyspepsia and spleen deficiency syndrome.

　　Method: use iodoacetyl group and joint small platform standing method or joint swimming method to establish functional dyspepsia and spleen deficiency rat models. By observing the general condition of animals, changes in body weight and food intake, serum motilin, cholecystokinin, lactic acid, gastrin content and urinary D-xylose excretion to evaluate the shaping effect.

　　Result: Rats in the iodoacetamide single-factor group lost weight and reduced food intake. Rats in the multifactorial group had symptoms of spleen deficiency, such as weight loss, curly hair, diarrhea, and urinary D incidence. -Xylose excretion and serum gastrin and gastrin content decreased significantly, and serum cholecystokinin and lactic acid content increased significantly.

　　Conclusion: The three modeling methods can all cause the symptoms of functional dyspepsia of spleen deficiency, but the symptoms of spleen deficiency are more obvious in the compound factor treatment group, and the iodoacetamide complex small platform standing method is the best.