动物造模,大鼠蛛网膜下腔出血模型 z-bio 2021-11-15 423

　　Objective: Through the combination of graphics and text, describe in detail the method and process of establishing a rat model of subarachnoid hemorrhage, and improve and innovate the model to better simulate the subarachnoid hemorrhage caused by the rupture of clinical aneurysm .

　　Method: Using the method of selecting SD male rats and infiltrating the internal and external cervical segments into the internal carotid artery, a model of subarachnoid hemorrhage in SD male rats was established to carry out the anatomy of breathing, pupils, urine and defecation . . Verify the model by indwelling the fiber core head and neck. Through observing mortality and clinical symptoms, the controllability and repeatability of the model were discussed.

　　Result: Vascular puncture will cause subarachnoid hemorrhage, and the position of the fiber core can accurately puncture the desired blood vessel.

　　Conclusion: The method is stable, easy to understand, well-designed, flexible and reproducible. The model can be successfully modeled in a short time after understanding, and can improve the subarachnoid hemorrhage caused by the successful model. Perform a sudden simulation. Clinical aneurysm rupture and bleeding. It is very suitable for the study of early brain injury and vasospasm of subarachnoid hemorrhage.