动物造模,舒张性心力衰竭实验动物模型 z-bio 2021-02-25 773

　　Diastolic heart failure, also known as heart failure with normal ejection fraction or heart failure with preserved ejection fraction, refers to patients with clinical symptoms and/or signs of heart failure, but lvef is normal or close to normal (lvef>50% or ﹥45%), there is evidence of left ventricular diastolic dysfunction, left ventricular end-diastolic diameter/body surface area<3.7cm/m2, and other valvular heart diseases are excluded. The 2013 Heart Failure Treatment Guidelines published by the American College of Cardiology Foundation/American Heart Association (americaN college of cardiology fouNdatioN/americaN heart associatioN, accf/aha) pointed out that dhf accounts for about 50% of heart failure, and the incidence is increasing year by year. .

　　The characteristic of dhf is that the onset population is older, more common in women, and common complications include diabetes, hypertension and myocardial ischemia. In the pathogenesis of dhf, the status of age, hypertension, and diabetes is particularly valued. At present, there are no effective therapeutic drugs for dhf in clinic, and prevention and treatment strategies are mainly aimed at its pathophysiological mechanism. Therefore, the establishment of animal models of diastolic heart failure induced by different factors can help us to further study and find effective intervention methods. This article will review the preparation methods of dhf animal models at home and abroad in recent years.