动物造模,异常黑胆质证大鼠模型 z-bio 2021-03-01 266

　　Purpose: Do you want to combine the observation of external characteristics and the study of urine metabolomics to evaluate and discuss the biological markers in the rat model of Uyghur medical abnormal sava syndrome?

　　Method: Uyghur medical abnormalities use Savda biliary tract theory to establish a rat animal model, observe and score various external indicators, such as hair, tongue, sleep, stool, mood, weight gain rate, 1H? Use nuclear magnetic resonance (1H? Nuclear magnetic resonance, 1H? NMR) to detect and analyze urine?

　　Result: Compared with the control group, the rats in the Savera bile syndrome model group had dry and hard stools, reduced urine output, dark, dry fur, and dark purple tongue coating. The content of 23 metabolites in this substance is greatly reduced. Creatine? Creatinine? Creatinine? Beta? Galactose? Urate? Tyrosine? Phenylalanine? Uric acid? Amino hippuric acid? Does the content of four metabolites of formic acid and lysine, urea, citric acid, allantoin and α-ketoglutarate increase significantly?

　　Conclusion: The rats in the model group not only showed appearance during the development of abnormal barbarism syndrome, but also had obvious changes in various internal metabolic pathways. The abnormality of metabolites in urine is biological, which may be related to scombroid abnormality. related.