动物造模,III期压疮模型纤维结合蛋白 z-bio 2021-11-03 394

　　Purpose: This study aims to investigate the mechanism of the effect of rose and cream on the levels of fibronectin (FN) and basic fibroblast growth factor (BFGF) in granulation tissue of rats with bedsore?

　　Method: Randomly select the 32SD rat sham operation group, and transplant the remaining 96 rats under bilateral granulation cells and magnetic plates to compress ischemia and reperfusion on a regular basis. The mice with stage III pressure ulcer models were randomly divided into model groups, and they were positive. After 4 days, the control group, rose and cream group were externally applied with saline gauze, the positive control group was externally applied with hydrocolloid dressing, and the rose and cream group were externally applied with rose and cream cloth. At the end of the treatment of the pressure ulcer site, the effective time of the pressure ulcer wound, the pressure ulcer healing rate and the healing rate were calculated, and the blood in the tail vein of the rat was measured from 3 days to 3 days. The 7th to 14th to 21st days of treatment. Serum levels of inflammatory mediators interleukin-1β (interleukin-1β, IL-1β), interleukin-6 (interleukin-6, IL-6) and C-reactive protein (CRP), whether the solid-phase sandwich method uses enzyme-linked immunosorbent assay To detect the levels of FN and BFGF in the granulation tissue of bedsores?

　　Result: The effectiveness and healing time of rose and cream is shorter than that of rose and cream. The positive control, wound healing and wound healing rate are all higher than the positive control. There are differences between the two groups. Meaning (P\u003c0.05)? On the 14, 21 and 28 days of treatment, the CRP and IL of the venous blood in the rose and cream group? 1β? IL? At 6 o'clock, it was significantly lower than the level of the model group and the positive control group (P\u003c0.05), while the BFGF and FN were significantly higher than the level of the model group and the positive control group. At the same time (P\u003c0.05, u003c0.05)?

　　Conclusion: Are roses and creams IL as inflammatory mediators? 6? IL? It may inhibit the inflammatory response caused by 1β, thereby reducing the damage of pressure ulcer wounds and increasing the synthesis of BFGF and FN, thereby promoting the proliferation of stromal cells and the synthesis of extracellular matrix, thereby promoting the regeneration and repair of wound granulation tissue.