动物造模,大鼠恐惧应激模型 z-bio 2021-11-04 292

　　Objective: How to establish rat models of different degrees of fear stress and explore the effect of fear stress on the visual cognition of LE rats?

　　Method: Using foot electric shock as a pressure stimulus, design a cognitive choice experiment and collect the neural response signals of the amigadala brain in this area for functional network analysis to produce visual cognitive effects in rats. Do you want to rate it? First, the experimental rats are divided into strong (S +), weak (S) fear stress group and control group (N), each group has a different intensity. Electric shock stimulation of the sole. Next, a single graphic "△" visual cognition enhancement training will be carried out. Finally, do you want to use dual images ("△" and "10" graphics) for visual selection test experiments? In addition, the network theory used to establish complex combined fears characterizes the visual cognitive network of the stressed rat's Amigdara nucleus through the stress average line length and clustering coefficient, which characterizes the signal conduction efficiency of the brain function network.

　　Result: The time required to complete the visual cognitive intensive training, S + S group? The S group was significantly higher than the N group in the early stage of intensive training, while the N group was significantly higher than the N group, and there was no significant difference between the two groups in the later stage. In the cognitive choice experiment, both the S and N groups formed a visual cognitive connection, but the S+ group did not. Brain function network analysis can form effective visual communication between Smigdala neurons. There are groups and N groups, but don't they form an S+ group?

　　Conclusion: Will fear pressure adversely affect visual cognition, and as the degree of fear increases, will the cognitive effect significantly worsen?