动物造模,去势导致雄性小鼠骨质疏松 z-bio 2021-12-09 669

　　Objective: To observe the therapeutic effect of bakuchiol on osteoporosis in male mice caused by castration.

　　Method: ICR male mice were randomly divided into 5 groups, namely control group, castration model group, positive drug group, perthiol 10mg/kg and 20mg/kg body recombination, and the control group after sham operation. Remove the testicles of the mice. After 6 weeks of successful modeling, the mice were treated with the drug for 8 weeks to detect serum biochemical indicators. The right tibia of each group was used for MicroCT scan, and the femur of each group was used for bone biomechanics measurement.

　　Results: The osteocalcin OC levels of the control group, model group, B10 and B20 mg/kg groups were (177.69±45.13), (220.35±25.08), (167.48±74.11) and (108.76±38.17), respectively. The Tb.N of the model group, the positive drug group, and the B10 and B20 mg/kg groups were (3.53±0.49), (1.71±016), (2.51±0.35), (2.14±0.23) and (2.45±0.42).

　　Conclusion: Bakuchiol has a therapeutic effect on osteoporosis in mice caused by castration.