疾病动物模型,帕金森病猕猴模型 z-bio 2021-03-08 260

　　Parkinson’s disease is the world’s second largest neurodegenerative disease after Alzheimer’s, and poses a serious threat to the health of middle-aged and elderly people. Li Xiaojiang and his collaborators from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences obtained 6 transgenic Parkinson’s disease macaques. This is the first successful preparation of a transgenic monkey model of Parkinson's disease in the world, and it provides important animal models for early pathogenesis research and early intervention and treatment of Parkinson's disease.

　　According to reports, the discovery and diagnosis of Parkinson’s disease is often in the middle and late stages of the disease course, resulting in unsatisfactory treatment effects. However, due to the lack of ideal animal models in the study of the early pathological mechanism of Parkinson’s disease, little is known about the early pathogenesis and targeted treatment of the disease. Rhesus monkeys and humans are highly similar in neurophysiological structure and behavior, and are ideal experimental animals for studying neurological diseases.

　　Li Xiaojiang and others established the first rhesus monkey model of neurodegenerative disease (Huntington's disease) in 2008 at Emory University in the United States. Using a similar transgenic method, Li Xiaojiang's research group cooperated with Ji Weizhi Laboratory, a researcher at the Yunnan Chinese Science Primate Biomedical Key Laboratory, and obtained 6 transgenic Parkinson’s disease macaques through 4 years of hard work. The oldest transgenic monkey with Parkinson's disease (Parkinson's disease) began to show cognitive memory, fine motor impairment, anxiety and depression symptoms at the age of 2.5. These features are the same as the early clinical manifestations of Parkinson's disease (Parkinson's disease) before the movement disorder appears. It fits very well.

　　The research was funded by the "973" project of the Ministry of Science and Technology, the National Natural Science Foundation of China and the State Key Laboratory of Molecular Developmental Biology.