疾病动物模型,纵隔神经性房速模型 z-bio 2021-03-09 267

　　[Model mechanism] The medial nerve is a mixed nerve plexus, including the parasympathetic preganglionic nerve, sympathetic afferent nerve and limb afferent nerve. The right mediastinal nerve mainly innervates the abdomen near the caudal side of the superior vena cava adjacent to the sinus node, and electrical stimulation of the right mediastinal nerve transfers the pacemaker from the sinus node to the right atrium, inducing atrial tachycardia. become.

　　[Modeling method] Dog: Please choose an adult male or female dog. After anesthesia, the chest cavity was opened, and formaldehyde was injected into the atrioventricular junction to block the atrioventricular conduction, and the ventricle beats at a rate of 60 beats per minute. During the atrial refractory period, the right mediastinal nerve S1S1 was stimulated with an intensity of 1-2 mA, a pulse width of 1 ms and an interval of 5 ms to induce tachycardia.

　　[Model Features] This model first shows bradycardia and then tachycardia.

　　[Model Evaluation and Application] can be used to study the role of autonomic nerves in rapid atrial attacks.