疾病动物模型,自发性心肌病 z-bio 2021-03-09 264

　　[Modeling mechanism] BIO14.6 hamster spontaneous cardiomyopathy model has been used for more than 30 years. This is because animals of this lineage carry a single gene deletion or mutation in the delta 2 glycoglycan, which leads to the spontaneous formation of DCM during myocardial development. Based on BIO14.6 hamsters, some strains such as UMX7.1, CHF147, TO-2 were also formed through screening and breeding.

　　[Model Features] BIO14.6 hamsters have myocardial degeneration/lysis 30-40 days after birth, 60-90 days myocardial fibrosis, myocardial hypertrophic cardiomyopathy at 150 days, DCM at 250 days, and congestive heart failure after 1 year of birth Appears later. The pathological characteristics of DCM in this strain of animals are similar to those of humans. At each stage, DCM has typical changes, such as small local myocardial necrosis and inflammatory cell infiltration. Cardiac fibrosis and cardiomyocyte hypertrophy, ventricular hypertrophy, accompanied by systemic changes such as ascites, liver and spleen congestion and swelling.

　　[Model Evaluation and Application] This hamster is very stable, more than 90% of animals eventually develop congestive heart failure, and the pathological features of dilated cardiomyopathy are similar to humans. Because the myocardium of this model animal has various characteristics such as degeneration, necrosis, hypertrophy and fibrosis, it is suitable for the study of myocardial degeneration and anti-fibrosis therapeutic agents and the study of myocardial molecular mechanism. Degeneration and necrosis. However, this model animal is relatively expensive and must be imported from abroad to reduce its practicality.