动物模型 z-bo 2020-08-04 633

　　Due to uncontrolled and massive proliferation of osteoblasts, osteosarcoma is the most common type of bone tumor. The two genes p53 and R6 are associated with sporadic and hereditary osteosarcoma. The b and p53 double knockout mice may show symptoms of osteosarcoma, with tumor features very similar to humans, and can metastasize to the lung and liver. The mouse model can be used to observe the progression of the disease. The organs where cancer cells metastasize are the same as those from human osteosarcoma patients.

　　TWIST and APC are two signal transduction factors that are very important for normal bone development. When crossed with twisted null/+ and Apc1638N/+ mice, Ape1638N/+ twisted null/+ mice can spontaneously form osteosarcoma without an inducer.