动物模型 z-bo 2020-08-04 504

　　The specific cause of psoriasis has not yet been fully elucidated, but more and more evidence supports the role of T lymphocytes in it.

　　[Modeling mechanism] Severe combined immunodeficiency mice (SCID mice) lack functional lymphocytes and are usually used to study the differentiation and function of immune cells. It is a common animal model in the fields of heterologous immune function remodeling, human autoimmune diseases, immunodeficiency diseases, infectious diseases and tumors. CD4 +/CD45RBhiT lymphocytes transplanted into SCID mice can induce psoriasis model.

　　[Model Features] In successfully transplanted mice, the occurrence of psoriasis-like symptoms is 100% within 4 to 8 weeks. However, SCID mice transplanted with CI4 +/CD4SRBloT lymphocytes did not look like psoriasis, and after co-transplantation with CD4 +/CD45RBhi and CD4 +/CD45RBloT lymphocytes, the symptoms of the mice were relieved. Narrowband ultraviolet rays and cyclosporin A have a therapeutic effect on the model.

　　[Model Evaluation and Application] The success of the T cell transplantation model shows that the dysfunction of regulatory T cell subsets plays an important role in the pathogenesis of psoriasis. Even if the original representative skin cells are normal, it may still cause psoriasis. The construction of this model transfers psoriasis research from the "single factor" stage to the "holistic" stage. In addition, this model can be used to screen drugs for the treatment of psoriasis.