疾病动物模型,酒精性肝硬化动物模型 z-bio 2021-03-10 341

　　[Modeling mechanism] Acetaldehyde is an intermediate metabolite of ethanol, which directly damages the liver, converts coenzyme I (NAD) into reduced coenzyme I (NADH) in the liver, and reduces the ratio of NAD/NADH, thereby inhibiting three carboxylic acid. Then, the oxidation of fat is weakened and fatty liver is formed, which eventually leads to liver fibrosis and cirrhosis.

　　[Modeling Method] Provides a mixture of ethanol (56%) and olive oil at the same time. The initial dose of white wine in rats is 8 g/kg, and it is increased by 2 g every 2 weeks, thereby increasing to 16 g. /kg. It will last for 16 weeks. [Model features] Within 4 weeks of modeling, the central part of the liver lobules was obviously necrotic, local or punctate necrosis, inflammatory infiltration into the interstitium, and fibrous proliferation was seen in the collagen around the liver cells under the action of electrons.

　　[Model Evaluation and Application] Due to the high incidence of liver fibrosis, convenient modeling and stable model, it can be widely used in the research of alcoholic liver disease, and can also be used as alcoholic fatty liver.