黑素瘤 z-bo 2020-08-04 572

　　[Modeling mechanism] Some species may spontaneously develop melanoma lesions due to their specific genetic background.

　　[Characteristics of the model] The genetic background of South American possums is not clear, and possums may spontaneously develop melanoma. Angora sheep is another animal model that spontaneously develops melanoma, and Angora sheep can also develop squamous cell carcinoma spontaneously. The incidence of melanoma is 2.2%, mainly behind the ear. There are many similarities between the skin of miniature pigs and human skin, and various melanoma lineages have been constructed. In 1967, a successful Sinclair minipig breed increased the incidence of skin melanoma, and its histology was similar to human superficial melanoma. A mini-pig melanoma cell line has also been established. Mini-pig tumors are usually nodular and multiple, distributed in different parts of the human body. The tumor itself may spread to multiple organs.

　　[Model Evaluation and Application] The developmental conditions of naturally occurring animal models of melanoma are natural, and careful observation, statistics, environment and other carcinogenic factors are used to determine the genetic characteristics, growth and degeneration of tumors. Useful for compliance with laws, host relationships and end results. wait. However, it is not easy to control the occurrence of tumors, it takes a long time and is economically large, and it is difficult to obtain a large amount of oncology data in a short time, and its application is limited.

　　Angora sheep model can be used to study the relationship between the onset site and melanoma, and is expected to provide a platform for studying the etiology of melanoma caused by light irradiation.

　　The

　　ipipig melanoma model is similar to human melanoma, which provides a model for studying tumor occurrence, development and regression. This model can be used to study the pathology, immunology, biochemistry, molecular biology and genetics of melanoma.