疾病动物模型,视网膜视锥细胞 z-bio 2021-03-12 313

　　[Modeling mechanism] The middle-wavelength opsin cone dysfunction (MCD) rat in the retinal cone cells is a spontaneous gene mutation rat discovered by the Department of Aerospace Medicine of the Fourth Military Medical University. It is manifested as the existence of dark-adapted ERG, but the feature that the light-adapted ERG cannot be recorded. It is the only known spontaneous mutant animal model with loss of retinal cone function, which provides for the development of retinal physiology and retinal diseases Condition.

　　[Model Features] The cone system of MCD is completely disabled, and the photosensitivity of the rod cells disappears completely under the stimulation of about 20Hz. However, the structure of the retina is roughly normal, and the density of pyramidal cells is normal. The disappearance of the M-opsin protein of the outer disc membrane is the pathogenic gene Opn1wm. There are only medium-wavelength and short-wavelength opsin in rat cone cells, and the medium-wavelength opsin is the main component. When the retina loses the expression of M-opsin protein, the photopic vision is severely damaged.

　　[Model Evaluation and Application] There are few animal models for studying day-blindness. MCD rats behave similarly to human blue monocular color blindness, which provides a theoretical basis for studying this disease.