[Animal model]-Spontaneous basal cell carcinoma model

动物模型,基底细胞癌

z-bo

2020-08-04

549

Basal cell carcinoma (BCC) may be derived from primitive epithelial germ cells and is mainly composed of mesenchymal-dependent pluripotent basal-like cells. It is a low-grade malignant tumor that differentiates into the epidermis or accessory organs. BCC animal models are divided into spontaneous animal models and genetically modified animal models.

　　 Spontaneous basal cell carcinoma model characteristics and mechanism

　　 [Modeling mechanism] With age, dogs and cats can spontaneously develop BCC. The specific mechanism is unknown, and it is speculated to be related to excessive sunlight.

　　 [Model Features] Dogs are more common in elderly dogs, especially poodles and cocker spaniels. Tumors are more common in the head, neck and shoulders of dogs. It appears as an isolated mass with a clear boundary. This disease accounts for 13% to 18% of cat skin tumors, and its performance is similar to that of dogs. The pathological manifestations of canine or cat BCC are very similar to human BCC.

　　【Model Evaluation and Application】Currently, research on these two types of animal models is only seen in veterinarians.