动物模型 z-bo 2020-08-04 708

　　[Modeling mechanism] Hyperfunction of sebaceous glands is one of the pathogenesis of acne vulgaris. Pigmented spots of sebaceous glands on the back of golden hamsters (also called flank organs) are androgen-dependent organs, which can be used to study anti-androgen and anti-sebaceous gland hyperplasia.

　　[Characteristics of the model] The experimental animals are male golden hamsters, raised in a single cage, and the experimental environment and breeding conditions must be constant. If you are studying topical drugs, shave your hair with an electric razor before the experiment. In order to prevent the animal from licking, the animal’s neck or body must be effectively fixed for at least 3 hours after each application. The sebaceous gland spots on the right side of the animal were applied twice a day, and the left side was left untreated for data correction. A control group was also set up. The maximum diameter D value and the maximum transverse diameter H value of the sebaceous gland plaques were measured, and the numerical changes were positively correlated with the volume of the sebaceous gland plaques.

　　[Model Evaluation and Application] This model uses the similarity of animal biological characteristics to human diseases as a disease model, which is called a biomedical animal model. Quantitative evaluation of drug efficacy by morphological methods has certain value.