动物模型 z-bo 2022-02-04 466

　　Congestion syndrome (blood loss syndrome) is caused by qi deficiency, qi stagnation, heat toxins, cold blood, etc., which block blood flow and accumulate in the meridians or organs. Or, due to various reasons, menstrual blood will not be lost and disappear in time. Caused by somewhere.

　　[Modeling mechanism] Various methods can be used to create an animal model of congestion syndrome, such as a microcirculation disorder congestion model by intravenous injection of polymer dextran, a spontaneous aging congestion model, and a rabbit abdominal autologous blood clot and congestion model. , Isoproterenol-induced myocardial infarction and congestion model.

　　[Modeling method] Using polymer dextran, 10% polymer dextran, weight 5 ml/kg body weight, 2 days a day in the rabbit ear veins to improve blood concentration and viscosity can be continuously injected for several days. [Characteristics of the model] Changes in hyperemia, such as whole blood viscosity, increase in plasma viscosity, and decrease in microcirculation blood flow, last for 2 days.

　　Model evaluation and application This method is simple and practical, but you should avoid excessive use of simulated drugs. It can be used in the research of blood activating and removing blood stasis drugs. For example, it is used in the pharmacological research of Chinese medicine, such as ectopic pregnancy No. 2, ectopic pregnancy No. 2, spring injection, tan deep injection and water ech, as well as ectopic pregnancy, atherosclerosis, intracranial hematoma And other treatment research.