How to prepare animal model of rheumatoid arthritis (Bi disease)?
类风湿关节炎,动物模型
z-bo
2020-08-04
564
Rheumatoid arthritis is an autoimmune disease represented by polyarthritis, which mainly includes TCM syndromes, such as cold arthritis, hyperthermia arthritis and Zube's syndrome.
[Modeling mechanism] Currently, most of the ideas for creating joint pain models are based on Western medicine rheumatoid arthritis disease models (mainly collagen-induced arthritis), and are compatible with the etiology and etiology of Chinese medicine. Provide compounds. As a factor of the evidence-based modeling method for establishing the TCM syndrome model of rheumatoid arthritis. Traditional Chinese medicine believes that the causes of joint pain are liver and kidney dysfunction, cold wind, penetration of moisture or rheumatism, and blockage of the meridians. Therefore, a method to simulate the cold subchondral process (cold subchondral process) using artificial air to cool a humid environment or in combination with Staphylococcal Enterotoxin B (SEB, as a superantigen that activates the immune response)? However, hot compresses (damp-heat arthritis) use artificial rheumatism. SEB stimulation in a thermal environment (renal arthritis syndrome) uses ovariectomy and castration (causes of renal failure) as modeling tools.
